Marbe Pharma
Core business

Heparin and derivatives

Supply and production technology across the whole heparin chain, from the first intermediate to the injectable API, under the technical supervision of experts with more than 40 years in the field.

Production process

From porcine mucosa to injectable heparin

We know every stage of the process and the critical quality points of each one. That knowledge underpins how we select sources and advise producers.

  1. 01

    Porcine intestinal mucosa

    Heparin is found in the intestinal mucosa. The quality of collection determines the whole downstream process.

  2. 02

    Heparin on Resin (HOR)

    Through a physico-chemical process, heparin binds to a cationic resin. This is the first intermediate in the chain.

  3. 03

    Crude heparin

    Further physico-chemical steps separate and concentrate the heparin, yielding crude heparin.

  4. 04

    Injectable heparin

    Final processing produces pharmaceutical-grade unfractionated heparin, which is also the basis for low molecular weight heparins (LMWH).

Products

Heparin and glycosaminoglycan range

For each product we offer supply and, when the project requires it, production technology.

Intermediate

Heparin on Resin (HOR)

First intermediate obtained from porcine mucosa, for crude heparin producers.

Intermediate

Crude heparin

Raw material for manufacturing injectable heparin and low molecular weight heparins.

API

Unfractionated injectable heparin

Heparin sodium of porcine and bovine origin (HALAL certified), and heparin calcium.

API

Low molecular weight heparins

Enoxaparin sodium for the manufacture of finished dosage forms.

GAGs

Glycosaminoglycans

Chondroitin sulfate of bovine and porcine origin, and heparinoids.

Other salts

Lithium heparin

For applications that require this specific salt, such as diagnostic use.

Services to the sector

We support producers and collectors

Explore technical services and consulting

  • Quality improvement for crude heparin producers

    Review of the process and analytical procedures to meet the specifications required by API manufacturers.

  • Porcine mucosa collectors

    Support to move into producing Heparin on Resin or crude heparin and add value to the raw material.

  • Technical advisory and production technology

    Process improvement, analytical procedures, plant design and technology transfer.

Expertise

Technical knowledge you can rely on

40+
years of direct experience in production, analytical control and GMP compliance
20+
years of experience in heparin analysis
GMP
design, implementation and operation of heparin and derivatives plants

Our technical partner, Mr. Hitendra Mehta, spent more than four decades at Scientific Protein Laboratories (USA), and we work with a network of senior technical and regulatory experts for complex projects.

Need heparin, HOR or a technical partner for your plant?

Tell us about your project and we will reply personally.

Contact us